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【结 构 式】 
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【药物名称】 【化学名称】4-[5-(4-Chlorophenyl)-3-(3'-methoxybiphenyl-4-yl)-1H-pyrrol-2-yl]pyridine 【CA登记号】 【 分 子 式 】C28H21ClN2O 【 分 子 量 】436.94537 |
【开发单位】Merck & Co. (Originator) 【药理作用】Antidiabetic Drugs, ENDOCRINE DRUGS, Glucagon Antagonists |
合成路线1
The alkylation of 4-(dimethoxymethyl)pyridine (I) with 4-bromobenzyl bromide (II) in the presence of n-butyllithium, followed by ketal hydrolysis with formic acid provided the diaryl ethanone (III). Further alkylation of (III) with 4-chlorophenacyl bromide (IV) employing sodium hexamethyldisilazide yielded diketone (V), which was cyclized in the presence of ammonium acetate in boiling AcOH to produce pyrrole (VI). Finally, Suzuki coupling of (VI) with 3-methoxybenzeneboronic acid (VII) by means of Pd(PPh3)4 furnished the title compound.
| 【1】 McMillan, M.; Cudaback, E.; Misra-Press, A.; et al.; Synthesis and biological studies of a novel inhibitor of NF-kappaB. 217th ACS Natl Meet (March 21 1999, Anaheim) 1999, Abst MEDI 213. |
| 【2】 de Laszlo, S.E.; Kim, D.; Chang, L.L.; Mantlo, N.B. (Merck & Co., Inc.); Substd. pyridyl pyrroles, compsns. containing such cpds. and methods of use. US 5776954 . |
| 【3】 De Laszlo, S.E.; Chang, L.L.; Kim, D.; Mantlo, N.B. (Merck & Co., Inc.); Substd. pyridyl pyrroles, compsns. containing such cpds. and methods of use. EP 0859771; JP 1999514651; WO 9716442 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29418 | 4-(dimethoxymethyl)pyridinemethoxy(4-pyridinyl)methyl methyl ether | C8H11NO2 | 详情 | 详情 | |
| (II) | 16109 | 1-bromo-4-(bromomethyl)benzene; 4-Bromobenzyl bromide | 589-15-1 | C7H6Br2 | 详情 | 详情 |
| (III) | 29423 | 2-(4-bromophenyl)-1-(4-pyridinyl)-1-ethanone | C13H10BrNO | 详情 | 详情 | |
| (IV) | 16720 | 2-bromo-1-(4-chlorophenyl)-1-ethanone; 2-Bromo-4'-chloroacetophenone | 536-38-9 | C8H6BrClO | 详情 | 详情 |
| (V) | 29424 | 2-(4-bromophenyl)-4-(4-chlorophenyl)-1-(4-pyridinyl)-1,4-butanedione | C21H15BrClNO2 | 详情 | 详情 | |
| (VI) | 29425 | 4-[3-(4-bromophenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine | C21H14BrClN2 | 详情 | 详情 | |
| (VII) | 29426 | 3-methoxyphenylboronic acid | 10365-98-7 | C7H9BO3 | 详情 | 详情 |