-Drug Synthesis Database

【结构式】

【药物名称】

【化学名称】2-[Hydroxy(4-nitrophenyl)methyl]acrylonitrile
　　　　　　3-Hydroxy-2-methylene-3-(4-nitrophenyl)propionitrile

【CA登记号】

【分子式】C₁₀H₈N₂O₃

【分子量】204.18686

【开发单位】Indian Institute of Technology (Originator)

【药理作用】ANTIINFECTIVE THERAPY, Antimalarials, Treatment of Protozoal Diseases

合成路线1

The title compound was synthesized through Baylis-Hillman reaction of p-nitrobenzaldehyde (I) with acrylonitrile (II) in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) and NaI.

参考文献中间体

【1】 Kundu, M.K.; et al.; Antimalarial activity of 3-hydroxyalkyl-2-methylene-propionic acid derivatives. Bioorg Med Chem Lett 1999, 9, 5, 731.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18184	4-Nitrobenzaldehyde	555-16-8	C₇H₅NO₃	详情	详情
(II)	10847	Acrylonitrile	107-13-1	C₃H₃N	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)