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【结 构 式】 
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【药物名称】VUF-K-8788 【化学名称】7-[3-[4-(2-Quinolinylmethyl)-1-piperazinyl]propoxy]-3,4-dihydro-2H-1,4-benzothiazin-3-one 【CA登记号】219741-10-3 【 分 子 式 】C25H28N4O2S 【 分 子 量 】448.59151 |
【开发单位】Kowa (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, RESPIRATORY DRUGS, Histamine H1 Antagonists |
合成路线1
The alkylation of N-formylpiperazine (II) with 2-(chloromethyl)quinoline (I) produced the disubstituted piperazine (III). The formyl group of (III) was then cleaved by means of H2SO4 in boiling EtOH, yielding quinolylmethylpiperazine (IV). Subsequent alkylation of (IV) with 1-bromo-3-chloropropane (V) afforded the chloropropyl derivative (VI). This was finally condensed with 7-hydroxybenzothiazinone (VII) in the presence of K2CO3 and a phase-transfer catalyst to furnish the title compound.
| 【1】 Tohma, T.; Onogi, K.; Zang, M.; Timmerman, H.; Wada, Y.; Tamura, M. (Kowa Co., Ltd.); Diamine derivs. and pharmaceutical containing the same. EP 0957100; WO 9902520 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13162 | 2-(Chloromethyl)quinoline; alpha-Chloroquinaldine | 4377-41-7 | C10H8ClN | 详情 | 详情 |
| (II) | 23801 | 1-piperazinecarbaldehyde; N-Formylpiperazine | 7755-92-2 | C5H10N2O | 详情 | 详情 |
| (III) | 41113 | 4-(2-quinolinylmethyl)-1-piperazinecarbaldehyde | C15H17N3O | 详情 | 详情 | |
| (IV) | 41114 | 2-(1-piperazinylmethyl)quinoline | C14H17N3 | 详情 | 详情 | |
| (V) | 10358 | 1-Bromo-3-chloropropane | 109-70-6 | C3H6BrCl | 详情 | 详情 |
| (VI) | 41115 | 2-[[4-(3-chloropropyl)-1-piperazinyl]methyl]quinoline | C17H22ClN3 | 详情 | 详情 | |
| (VII) | 28290 | 7-hydroxy-2H-1,4-benzothiazin-3(4H)-one | C8H7NO2S | 详情 | 详情 |