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【结 构 式】 
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【药物名称】 【化学名称】3'-Deoxy-2',3'-didehydro-5'-O-[(O-phenyl-L-alanino)(phenoxy)phosphoryl]thymidine 【CA登记号】 【 分 子 式 】C25H26N3O8P 【 分 子 量 】527.47507 |
【开发单位】Rega Institute for Medical Research (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Antiviral Drugs |
合成路线1
Title phosphoramidate was obtained by condensation of phenyl (phenoxyalanino)phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.
| 【1】 McGuigan, C.; Sutton, P.W.; Cahard, D.; Turner, K.; O'Leary, G.; Wang, Y.; Gumbleton, M.; De Clercq, E.; Balzarini, J.; Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T). Antivir Chem Chemother 1998, 9, 6, 473. |
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