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【结 构 式】

【药物名称】

【化学名称】3'-Deoxy-2',3'-didehydro-5'-O-[[O-(2-naphthylmethyl)-L-alanino](phenoxy)phosphoryl]thymidine

【CA登记号】

【 分 子 式 】C30H30N3O8P

【 分 子 量 】591.5627

【开发单位】Rega Institute for Medical Research (Originator)

【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Antiviral Drugs

合成路线1

Title phosphoramidate was obtained by condensation of phenyl [(2-naphthylmethoxy)alanino]phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.

1 McGuigan, C.; Sutton, P.W.; Cahard, D.; Turner, K.; O'Leary, G.; Wang, Y.; Gumbleton, M.; De Clercq, E.; Balzarini, J.; Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T). Antivir Chem Chemother 1998, 9, 6, 473.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 25322 2-naphthylmethyl (2S)-2-[[chloro(phenoxy)phosphoryl]amino]propanoate C20H19ClNO4P 详情 详情
(II) 25323 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione C10H12N2O4 详情 详情
Extended Information