-Drug Synthesis Database

【结构式】

【药物名称】

【化学名称】3'-Deoxy-2',3'-didehydro-5'-O-[[O-(2-naphthylmethyl)-L-alanino](phenoxy)phosphoryl]thymidine

【CA登记号】

【分子式】C₃₀H₃₀N₃O₈P

【分子量】591.5627

【开发单位】Rega Institute for Medical Research (Originator)

【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Antiviral Drugs

合成路线1

Title phosphoramidate was obtained by condensation of phenyl [(2-naphthylmethoxy)alanino]phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.

参考文献中间体

【1】 McGuigan, C.; Sutton, P.W.; Cahard, D.; Turner, K.; O'Leary, G.; Wang, Y.; Gumbleton, M.; De Clercq, E.; Balzarini, J.; Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T). Antivir Chem Chemother 1998, 9, 6, 473.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	25322	2-naphthylmethyl (2S)-2-[[chloro(phenoxy)phosphoryl]amino]propanoate		C₂₀H₁₉ClNO₄P	详情	详情
(II)	25323	1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione		C₁₀H₁₂N₂O₄	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)