Fluodipine, -Drug Synthesis Database

【结构式】

【药物名称】Fluodipine

【化学名称】2,6-Dimethyl-4-(9-oxo-9H-fluoren-4-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid bis(2-propenyl) diester

【CA登记号】145695-42-7

【分子式】C₂₈H₂₅NO₅

【分子量】455.51515

【开发单位】Università degli Studi di Bologna (Originator), Università degli Studi di Milano (Originator)

【药理作用】Angina pectoris, Treatment of, CARDIOVASCULAR DRUGS, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Calcium Channel Blockers

合成路线1

Fluorenone-4-carboxaldehyde (II) was obtained by reduction of acid chloride (I). Subsequent Hantzsch synthesis using allyl acetoacetate (III) and ammonium hydroxide in boiling isopropyl alcohol provided the title dihydropyridine.

参考文献中间体

【1】 Valenti, P.; Brudiesi, R.; Rampa, A.; Chiarini, A.; Fluorenone and benzophenone 1,4-dihydropyridine derivatives with cardiodepressant activity. Arzneim-Forsch Drug Res 1992, 42, 11, 1284.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29595	9-oxo-9H-fluorene-4-carbonyl chloride		C₁₄H₇ClO₂	详情	详情
(II)	29596	9-oxo-9H-fluorene-4-carbaldehyde		C₁₄H₈O₂	详情	详情
(III)	22675	allyl 3-oxobutanoate	1118-84-9	C₇H₁₀O₃	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)