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【结 构 式】 
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【药物名称】 【化学名称】(all-Z)-N-(2-Propynyl)-5,8,11,14-icosatetraenamide 【CA登记号】 【 分 子 式 】C23H35NO 【 分 子 量 】341.5415 |
【开发单位】National Hellenic Research Foundation (Originator), University of Connecticut (Originator) 【药理作用】Cannabinoid CB1 Agonists |
合成路线1
Title compound was prepared by formation of the arachidonic acid chloride (II) upon treatment of the corresponding acid (I) with oxalyl chloride in CH2Cl2 containing DMF at 0 C, followed by condensation with propargylamine (III).
| 【1】 Lin, S.; Khanolkar, A.D.; Fan, P.; Goutopoulos, A.; Qin, C.; Papahadjis, D.; Makriyannis, A.; Novel analogues of arachidonylethanolamide (anandamide): Affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. J Med Chem 1998, 41, 27, 5353. |
Extended Information