【结 构 式】 |
【药物名称】 【化学名称】4-(Acetyloxy)-6,7-dichloro-5,8-dioxo-5,8-dihydro-1-naphthalenyl acetate 【CA登记号】 【 分 子 式 】C14H8Cl2O6 【 分 子 量 】343.12226 |
【开发单位】China Medical College (Originator), National Taiwan University (Originator), University of North Carolina (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Antiplatelet Therapy, Asthma Therapy, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, RESPIRATORY DRUGS, Antiinflammatory Drugs |
合成路线1
Friedel Crafts condensation of p-dimethoxybenzene (I) with dichloromaleic anhydride (II) in a molten mixture of AlCl3 and NaCl yielded dihydroxynaphthoquinone (III). Subsequent acetylation with Ac2O and AcOH furnished the target diacetate.
【1】 Huang, L.-J.; Chang, F.C.; Lee, K.H.; Wang, J.P; Teng, C.M.; Kuo, S.C.; Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds. Bioorg Med Chem 1998, 6, 12, 2261. |
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