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【结 构 式】 
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【药物名称】 【化学名称】7-Chloro-6-fluoro-3-(4-methypiperazin-1-ylcarbonyl)-4(1H)-quinolinone 【CA登记号】 【 分 子 式 】C15H15ClFN3O2 【 分 子 量 】323.7571 |
【开发单位】Central Drug Research Institute (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antimalarials, Treatment of Protozoal Diseases |
合成路线1
Title compound was synthesized by condensation of ethyl 7-chloro-6-fluoro-4-quinolone-3-carboxylate (I) with N-methylpiperazine (II) in pyridine at 120 C under pressure.
| 【1】 Srivastava S; Srivastava, S.K.; Shukla, A.; Chauhan, P.M.; Puri, S.K.; Bhaduri, A.P.; Pandey, V.C.; Synthesis and methemoglobin toxicity of the amides of 6/7 mono or disubstituted quinolone. Bioorg Med Chem Lett 1999, 9, 1, 25. |
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