-Drug Synthesis Database

【结构式】

【药物名称】

【化学名称】N-[2-(3,4-Dimethoxyphenyl)ethyl]-4,5-dihydrooxazole-2-amine hydrochloride
　　　　　　N-(4,5-Dihydrooxazol-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]amine hydrochloride

【CA登记号】

【分子式】C₁₃H₁₉ClN₂O₃

【分子量】286.76098

【开发单位】China Pharmaceutical University (Originator)

【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of

合成路线1

Acid-catalyzed condensation of ethanolamine (I) with urea (II) produced oxazolidinone (III). Subsequent reaction of (III) with triethyloxonium fluoborate yielded ethoxyoxazoline (IV). This was finally condensed with 2-(3,4-dimethoxyphenyl)- ethylamine to afford the title compound, which was isolated as the hydrochloride salt.

参考文献中间体

【1】 Xu, J.Y.; et al.; Synthesis of imidazoline, oxazoline derivatives and antihypertensive activity. J Chin Pharm Univ 1998, 29, 5, 336.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10259	Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol；2-Aminoethyl alcohol	141-43-5	C₂H₇NO	详情	详情
(II)	19310	urea	57-13-6	CH₄N₂O	详情	详情
(III)	21456	1,3-oxazolidin-2-one	497-25-6	C₃H₅NO₂	详情	详情
(IV)	25692	4,5-dihydro-1,3-oxazol-2-yl ethyl ether; 2-ethoxy-4,5-dihydro-1,3-oxazole		C₅H₉NO₂	详情	详情
(V)	10098	2-(3,4-Dimethoxyphenyl)-1-ethanamine; 3,4-Dimethoxyphenethylamine; 2-(3,4-Dimethoxyphenyl)ethylamine	120-20-7	C₁₀H₁₅NO₂	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)