【结 构 式】 |
【药物名称】 【化学名称】7-Methyl-3-[(2-phenylethyl)sulfanylmethyl]imidazo[1,2-a]pyridine 【CA登记号】 【 分 子 式 】C17H18N2S 【 分 子 量 】282.41041 |
【开发单位】Rega Institute for Medical Research (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antiviral Drugs |
合成路线1
The cyclization of 4-methylpyridine-2-amine (I) with 2-bromoacetaldehyde (II) in refluxing ethanol gives 7-methylimidazo[1,2-a]pyridine (III), which by reaction with formaldehyde in refluxing acetic acid is converted into 7-methylimidazo[1,2-a]pyridin-3-ylmethanol (IV). Finally, this compound is condensed with 2-phenylethanethiol (V) in acetic acid at 100 C.
【1】 Gueiffier, A.; Mavel, S.; Lhassani, M.; Elhakmaoui, A.; Snoeck, R.; Andrei, G.; Chavignon, O.; Teulade, J.C.; Witvrouw, M.; Balzarini, J.; De Clercq, E.; Chapat, J.P.; Synthesis of imidazo[1,2-a]pyridines as antiviral agents. J Med Chem 1998, 41, 25, 5108. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 14616 | 4-Methyl-3-nitro-pyridin-2-ol; 4-Methyl-3-nitro-2-pyridinol | 21901-18-8 | C6H6N2O3 | 详情 | 详情 |
(II) | 24802 | 2-bromoacetaldehyde | C2H3BrO | 详情 | 详情 | |
(III) | 24803 | 7-methylimidazo[1,2-a]pyridine | C8H8N2 | 详情 | 详情 | |
(IV) | 24804 | (7-methylimidazo[1,2-a]pyridin-3-yl)methanol | C9H10N2O | 详情 | 详情 | |
(V) | 24805 | 2-phenyl-1-ethanethiol | C8H10S | 详情 | 详情 |
Extended Information