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【结 构 式】 
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【药物名称】 【化学名称】(Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]pyridine 【CA登记号】220114-73-8 【 分 子 式 】C17H19NO4 【 分 子 量 】301.34528 |
【开发单位】Ajinomoto (Originator) 【药理作用】ONCOLYTIC DRUGS, Antimitotic Drugs, Microtubule-Stabilizing Agents |
合成路线1
Title compound was prepared by Wittig reaction of 2-methoxypyridine-5-carboxaldehyde (I) with trimethoxybenzylphosphonium salt (II) in the presence of NaOMe, followed by chromatographic separation of the mixture of E and Z isomers.
| 【1】 Hatanaka, T.; Tanizawa, K.; Ohsumi, K.; Nakagawa, R.; Fukuda, Y.; Nihei, Y.; Suga, Y.; Akiyama, Y.; Tsuji, T.; Novel B-ring modified combretastatin analogues: Synthesis and antineoplastic activity. Bioorg Med Chem Lett 1998, 8, 23, 3371. |
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