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【结 构 式】

【药物名称】

【化学名称】(6R,8R,9R)-N-[4-Amino-9-(tert-butyldimethylsilyloxy)-6-(tert-butyldimethylsilyloxymethyl)-1,7-dioxa-2-thiaspiro[4.4]-3-nonen-8-yl]-N'-(2-methylpropenoyl)urea S,S-dioxide

【CA登记号】

【 分 子 式 】C24H45N3O8SSi2

【 分 子 量 】591.87755

【开发单位】CSIC (Originator), Rega Institute for Medical Research (Originator)

【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Reverse Transcriptase Inhibitors

合成路线1

The reduction of azide (I) with trimethylphosphine in THF gives the amine (II), which is then treated with methacryloyl isocyanate (III) in acetonitrile yielding a mixture of alpha and beta phenylureas which is separated by centrifugal circular thin layer chromatography.

1 Velázquez, S.; Chamorro, C.; Perez-Perez, M.J.; Alvarez, R.; Jimeno, M.L.; Martin-Domenech, A.; Perez, C.; Gago, F.; De Clercq, E.; Balzarini, J.; San-Felix, A.; Camarasa, M.J.; Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase. J Med Chem 1998, 41, 23, 4636.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 26923 (6R,8R,9R)-4-amino-8-azido-9-[[tert-butyl(dimethyl)silyl]oxy]-6-([[tert-butyl(dimethyl)silyl]oxy]methyl)-1,7-dioxa-2lambda(6)-thiaspiro[4.4]non-3-ene-2,2-dione C19H38N4O6SSi2 详情 详情
(II) 26924 (6R,8R,9R)-4,8-diamino-9-[[tert-butyl(dimethyl)silyl]oxy]-6-([[tert-butyl(dimethyl)silyl]oxy]methyl)-1,7-dioxa-2lambda(6)-thiaspiro[4.4]non-3-ene-2,2-dione C19H40N2O6SSi2 详情 详情
(III) 26925 2-methylacryloyl isocyanate C5H5NO2 详情 详情
Extended Information