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【结 构 式】 
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【药物名称】 【化学名称】N-(3-Phenyl-1,2,4-oxadiazol-5-ylmethyl)phthalimide
【CA登记号】219611-74-2 【 分 子 式 】C17H11N3O3 【 分 子 量 】305.29552 |
【开发单位】Universidade Federal da Paraiba (Originator), Universidade Federal de Pernambuco (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs |
合成路线1
Reaction of glycine (II) with phthalic anhydride (I) in a microwave oven gave phthaloylglycine (III). Subsequent condensation with phenylamidoxime (IV) in the presence of DCC in dimethoxyethane afforded the O-acyl intermediate (V), which on heating cyclized to the title oxadiazole.
| 【1】 Antunes, R.; Batista, H.; Srivastava, R.M.; Thomas, G.; Araujo, C.C.; New phthalimide derivatives with potent analgesic activity: II. Bioorg Med Chem Lett 1998, 8, 21, 3071. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11900 | 2-Benzofuran-1,3-dione;1,2-Benzenedicarboxylic Anhydride;1,2-BENZENE DICARBOXYLIC ACID ANHYDRIDE;1,2-BENZENEDICARBONIC ACID, ANHYDRIDE;1,3-DIOXOPHTHALAN;1,3-ISOBENZOFURANDIONE;o-phthalic anhydride; Phthalic anhydride | 85-44-9 | C8H4O3 | 详情 | 详情 |
| (II) | 20436 | glycine | 56-40-6 | C2H5NO2 | 详情 | 详情 |
| (III) | 11284 | (6aR,9R,10aR)-7-Allyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxylic acid | C18H20N2O2 | 详情 | 详情 | |
| (IV) | 20438 | N'-hydroxybenzenecarboximidamide | 613-92-3 | C7H8N2O | 详情 | 详情 |
| (V) | 20439 | 2-[2-([[(Z)-amino(phenyl)methylidene]amino]oxy)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione | C17H13N3O4 | 详情 | 详情 |
Extended Information