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【结 构 式】 
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【药物名称】Cymserine 【化学名称】N-[4-(1-Isopropylphenyl)carbamic acid (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ylester 【CA登记号】145209-39-8 【 分 子 式 】C23H29N3O2 【 分 子 量 】379.50648 |
【开发单位】Axonyx (Originator), National Institutes of Health (Codevelopment) 【药理作用】Alzheimer's Dementia, Treatment of , Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, Butyrylcholinesterase Inhibitors |
合成路线1
The title carbamate was prepared by condensation of (-)-eseroline (I) with 4-isopropylphenyl isocyanate in Et2O in the presence of a catalytic amount of Na.
| 【1】 Brzostowska, M.; et al.; Phenylcarbamates of (-)-eseroline, (-)-N1-noreseroline and (-)-physovenol: Selective inhibitors of acetyl and,or butyrylcholinesterase. Med Chem Res 1992, 2, 4, 238. |
| 【2】 Brossi, A.; Brzostowska, M.; Rapoport, S.I.; Greig, N.; He, X.-S. (US Department of Health & Human Services); Substd. phenserines as specific inhibitors of acetylcholinesterase. EP 0606366; JP 1995503703; US 5171750; WO 9306105 . |
Extended Information