|
【结 构 式】 
|
【药物名称】SCH-57790 【化学名称】2-(4-Cyclohexylpiperazin-1-yl)-2-[4-[(S)-4-methoxyphenylsulfinyl]phenyl]acetonitrile 【CA登记号】221660-80-6, 182136-73-8 (undefined isomer) 【 分 子 式 】C25H31N3O2S 【 分 子 量 】437.60872 |
【开发单位】Schering-Plough (Originator) 【药理作用】Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, Muscarinic M2 Antagonists |
合成路线1
Oxidation of disulfide (I) with sulfuryl chloride in AcOH at -20 C afforded (4-methoxyphenyl)sulfinyl chloride (II), which was condensed with (1R,2S)-2-phenylcyclohexanol to provide sulfinate (IV) as a single diastereomer. Subsequent condensation with the Grignard reagent (V) produced the chiral sulfoxide (VI). The diethyl acetal of (VI) was then hydrolyzed to the corresponding benzaldehyde (VII) using p-TsOH in THF-H2O. Finally, condensation of (VII) with N-cyclohexylpiperazine (VIII) using titanium tetraisopropoxide, followed by addition of diethylaluminum cyanide, furnished the target piperazinylacetonitrile.
| 【1】 Lowe, D.B.; Guzik, H.S.; Kozlowski, J.A.; et al.; Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor. Bioorg Med Chem Lett 2000, 10, 20, 2255. |
| 【2】 Lowe, D.; Chang, W.; Kozlowski, J.; Berger, J.G.; McQuade, R.; Barnett, A.; Scherlock, M.; Tom, W.; Dugar, S.; Chen, L.-Y.; Clader, J.W.; Chackalamannil, S. (Schering Corp.); Benzylpiperidines and piperazines as muscarinic an. EP 0811002; JP 1999501014; US 5883096; WO 9626196 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23167 | 1-methoxy-4-[(4-methoxyphenyl)disulfanyl]benzene; bis(4-methoxyphenyl) disulfide | 5335-87-5 | C14H14O2S2 | 详情 | 详情 |
| (II) | 23168 | 4-methoxybenzenesulfinyl chloride | C7H7ClO2S | 详情 | 详情 | |
| (III) | 23169 | (1S,2R)-2-phenylcyclohexanol | C12H16O | 详情 | 详情 | |
| (IV) | 23170 | (1S,2R)-2-phenylcyclohexyl 4-methoxybenzenesulfinate | C19H22O3S | 详情 | 详情 | |
| (V) | 23171 | bromo[4-(diethoxymethyl)phenyl]magnesium | C11H15BrMgO2 | 详情 | 详情 | |
| (VI) | 23172 | [4-(diethoxymethyl)phenyl](4-methoxyphenyl)oxo-lambda(4)-sulfane; 4-(diethoxymethyl)phenyl 4-methoxyphenyl sulfoxide | C18H22O4S | 详情 | 详情 | |
| (VII) | 23173 | 4-[(4-methoxyphenyl)sulfinyl]benzaldehyde | C14H12O3S | 详情 | 详情 | |
| (VIII) | 23174 | 1-cyclohexylpiperazine | 17766-28-8 | C10H20N2 | 详情 | 详情 |