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【结 构 式】 
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【药物名称】PH-98 【化学名称】3-(2-Nitrophenyl)-1-(2,3,4-trimethoxyphenyl)-2(E)-propen-1-one 【CA登记号】158117-42-1 【 分 子 式 】C18H17NO6 【 分 子 量 】343.33929 |
【开发单位】Danish University of Pharmaceutical Sci. (Originator), Statens Serum Institute (Originator) 【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY, Antileishmanials, Treatment of Protozoal Diseases |
合成路线1
Title compound was prepared by Claisen Schmidt condensation of 2'-nitroacetophenone (I) with 2,3,4-trimethoxybenzaldehyde (II) in EtOH using HCl as the catalyst.
| 【1】 Nielsen, S.F.; Christensen, S.B.; Gruciani, G.; Kharazmi, A.; Liljefors, T.; Antileishmanial chalcones: Statistical design, synthesis, and three-dimensional quantitative structure-activity relationship analysis. J Med Chem 1998, 41, 24, 4819. |
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