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【结 构 式】 
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【药物名称】ENC-22-HP 【化学名称】1-Cyclopropyl-7-[4-[2,2-bis(diethoxyphosphoryl)ethyl]piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 【CA登记号】 【 分 子 式 】C27H40FN3O9P2 【 分 子 量 】631.58055 |
【开发单位】ElizaNor Biopharmaceuticals (Originator) 【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY, Bisphosphonates, Quinolones |
合成路线1
The title compound was synthesized by condensation of cyprofloxacin (I) with tetraethyl ethenylidenebisphosphonate (II) in the presence of Et3N in CH2Cl2
| 【1】 Herczegh, P.; Buxton, T.B.; McPherson, J.C. III.; Kovács-Kulyassa, A.; Brewer, P.D.; Sztaricskai, F.; Stroebel, G.G.; Plowman, K.M.; Farcasiu, D.; Hartmann, J.F.; Osteoadsorptive bisphosphonate derivatives of fluoroquinolone antibacterials. J Med Chem 2002, 45, 11, 2338. |
| 【2】 Herczegh, P.; Sztaricskai, F.J.; Farcasiu, D.; Hartmann, J.F. (ElizaNor Biopharmaceuticals, Inc.); Diphosphonate derivs. of therapeutic agents. US 5880111; WO 9640190 . |
Extended Information