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【结 构 式】 
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【药物名称】 【化学名称】2-[2-(4-Fluorophenyl)benzofuran-3-yl]-N,N-dihexylacetamide 【CA登记号】 【 分 子 式 】C28H36FNO2 【 分 子 量 】437.60302 |
【开发单位】Georgetown University (Originator) 【药理作用】Anxiolytics, PSYCHOPHARMACOLOGIC DRUGS |
合成路线1
O-Phenylhydroxylamine hydrochloride (II) (prepared from potassium phenoxide (I) and hydroxylamine-O-sulfonic acid) was condensed with ketoamide (III) in refluxing EtOH to afford oxime (IV). This was converted to the target benzofuran by heating in a mixture of formic acid and phosphoric acid.
| 【1】 Liao, Y.; Kozikowski, A.P.; Guidotti, A.; Costa, E.; Synthesis and pharmacological evaluation of benzofuran-acetamides as "antineophobic" mitochondrial DBI receptor complex ligands. Bioorg Med Chem Lett 1998, 8, 16, 2099. |
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