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【结 构 式】 
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【药物名称】 【化学名称】(Z)-4-(4-Phenyl-1-butenyl)-1H-imidazole fumarate 【CA登记号】 【 分 子 式 】C17H18N2O4 【 分 子 量 】314.34401 |
【开发单位】Bioprojet (Originator) 【药理作用】Antiepileptic Drugs, Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, PSYCHOPHARMACOLOGIC DRUGS, Sleep Disorders, Treatment of, Histamine H3 Receptor Antagonists |
合成路线1
The Wittig condensation of 1-tritylimidazole-4-carbaldehyde (I) with triphenyl(3-phenylpropyl)phosphonium bromide (II) and potassium tert-butoxide in THF gives 4-(4-phenyl-1(Z)-butenyl)-1-trityl-1H-imidazole (III), which is deprotected with 6N HCl in refluxing acetone.
| 【1】 Stark, H.; Ligneau, X.; Arrang, J.-M.; Schwartz, J.-C.; Schunack, W.; General construction pattern of histamine H3-receptor antagonists: Change of a paradigm. Bioorg Med Chem Lett 1998, 8, 15, 2011. |
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