|
【结 构 式】 
|
【药物名称】L-776967 【化学名称】2-(3,5-Difluorophenyl)-3-[4-(methylsulfonyl)phenyl]-2-cyclopenten-1-one 【CA登记号】 【 分 子 式 】C18H14F2O3S 【 分 子 量 】348.37128 |
【开发单位】Merck & Co. (Originator) 【药理作用】Antiarthritic Drugs, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Cyclooxygenase-2 Inhibitors |
合成路线1
The bromination of 2-cyclopentenone (I) gives 2-bromocyclopentenone (II), which is condensed with 3,5-difluorophenylboronic acid (III) by means of a Pd catalyst yielding 2-(3,5-difluorophenyl)-2-cyclopentenone (IV). The reaction of (IV) with the aryl lithium (V) affords the cyclopentenol derivative (VI), which is submitted to an oxidation with PDC with simultaneous allylic transposition to give 2-(3,5-difluorophenyl)-3-[4-(methylsulfanyl)phenyl]-2-cyclopenten-1-one (VII). Finally, this compound is oxidized with H 2O2 (Na2WO4) to the target sulfone. The preceding synthetic approach can also be performed with 2-iodo-2-cyclopentenone (obtained by iodination of (I) instead of its bromo analogue (II). The synthetic approaches can also be performed with the arylmagnesium analogue of lithium derivative (V).
| 【1】 Black, C. (Merck Frosst Canada Inc.); 2-(3,5-Difluorophenyl)-3-(4-(methyl-sulfonyl)phenyl)-2-cyclopenten-1-one useful as an inhibitor of cyclooxygenase-2. EP 0863134; JP 1998251220 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25950 | 2-cyclopenten-1-one | 930-30-3 | C5H6O | 详情 | 详情 |
| (II) | 25951 | 2-bromo-2-cyclopenten-1-one | C5H5BrO | 详情 | 详情 | |
| (III) | 25952 | 3,5-difluorophenylboronic acid | 156545-07-2 | C6H5BF2O2 | 详情 | 详情 |
| (IV) | 25953 | 2-(3,5-difluorophenyl)-2-cyclopenten-1-one | C11H8F2O | 详情 | 详情 | |
| (V) | 18808 | [4-(methylsulfanyl)phenyl]lithium | C7H7LiS | 详情 | 详情 | |
| (VI) | 25954 | 2-(3,5-difluorophenyl)-1-[4-(methylsulfanyl)phenyl]-2-cyclopenten-1-ol | C18H16F2OS | 详情 | 详情 | |
| (VII) | 25955 | 2-(3,5-difluorophenyl)-3-[4-(methylsulfanyl)phenyl]-2-cyclopenten-1-one | C18H14F2OS | 详情 | 详情 |
合成路线2
The condensation of 2-bromo-2-cyclopentenone (II) with the aryl lithium compound (V) gives the tertiary alcohol (VIII), which is submitted to an oxidation with PDC with simultaneous allylic transposition to provide 2-bromo-3-[4-(methylsulfanyl)phenyl]-2-cyclopenten-1-one (IX). The oxidation of (IX) with H2O2 (Na2WO4) or MCPBA yields the corresponding sulfone (X), which is finally condensed with boronic acid (III) by means of a Pd catalyst as before. The synthetic approaches can also be performed with the arylmagnesium analogue of lithium derivative (V).
| 【1】 Black, C. (Merck Frosst Canada Inc.); 2-(3,5-Difluorophenyl)-3-(4-(methyl-sulfonyl)phenyl)-2-cyclopenten-1-one useful as an inhibitor of cyclooxygenase-2. EP 0863134; JP 1998251220 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 25951 | 2-bromo-2-cyclopenten-1-one | C5H5BrO | 详情 | 详情 | |
| (III) | 25952 | 3,5-difluorophenylboronic acid | 156545-07-2 | C6H5BF2O2 | 详情 | 详情 |
| (V) | 18808 | [4-(methylsulfanyl)phenyl]lithium | C7H7LiS | 详情 | 详情 | |
| (VIII) | 25956 | 2-bromo-1-[4-(methylsulfanyl)phenyl]-2-cyclopenten-1-ol | C12H13BrOS | 详情 | 详情 | |
| (IX) | 25957 | 2-bromo-3-[4-(methylsulfanyl)phenyl]-2-cyclopenten-1-one | C12H11BrOS | 详情 | 详情 | |
| (X) | 25958 | 2-bromo-3-[4-(methylsulfonyl)phenyl]-2-cyclopenten-1-one | C12H11BrO3S | 详情 | 详情 |
合成路线3
The bromination of 3-ethoxy-2-cyclopentenone (XI) gives the 2-bromo derivative (XII), which is condensed with the aryl lithium (V) as before yielding the tertiary alcohol (XIII). Then (XIII) was submitted to an acid rearrangement to provide 2-bromo-3-[4-(sulfanylmethyl)phenyl]-2-cyclopentenone (IX), already obtained in the preceding approaches. The synthetic approaches can also be performed with the arylmagnesium analogue of lithium derivative (V).
| 【1】 Chan, C.-C.; Brideau, C.; Black, W.C.; et al.; 2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors. J Med Chem 1999, 42, 7, 1274. |
| 【2】 Black, C. (Merck Frosst Canada Inc.); 2-(3,5-Difluorophenyl)-3-(4-(methyl-sulfonyl)phenyl)-2-cyclopenten-1-one useful as an inhibitor of cyclooxygenase-2. EP 0863134; JP 1998251220 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 18808 | [4-(methylsulfanyl)phenyl]lithium | C7H7LiS | 详情 | 详情 | |
| (IX) | 25957 | 2-bromo-3-[4-(methylsulfanyl)phenyl]-2-cyclopenten-1-one | C12H11BrOS | 详情 | 详情 | |
| (XI) | 25959 | 3-ethoxy-2-cyclopenten-1-one | C7H10O2 | 详情 | 详情 | |
| (XII) | 25960 | 2-bromo-3-ethoxy-2-cyclopenten-1-one | C7H9BrO2 | 详情 | 详情 | |
| (XIII) | 25961 | 2-bromo-3-ethoxy-1-[4-(methylsulfanyl)phenyl]-2-cyclopenten-1-ol | C14H17BrO2S | 详情 | 详情 |
合成路线4
The reaction of 4-(methylsulfanyl)acetophenone (I) with tosylhydrazine by means of PPTS in acetonitrile gives the corresponding hydrazone (II), which by reaction with isopropylmagnesium chloride in THF/toluene yields the vinylmagnesium derivative (III). This compound, without isolation is condensed with 3,5-difluorobenzaldehyde (IV) to afford the allyl alcohol (V), which is condensed with triethyl orthoacetate and saponified providing 5-(3,5-difluorophenyl)-4-[4-(methylsulfanyl)phenyl]-4-pentenoic acid (VI). The cyclization of (VI) with AlCl3 and (COCl)2 in dichloromethane gives the cyclopentenone (VII), which is finally oxidized with potassium peroxymonosulfate (Oxone) in hot acetone/water to afford the target sulfone.
| 【1】 Grabowski, E.J.J.; Zhaol, D.L.; Prasit, P.; Xu, F.; Ouimet, N.; Tillyer, R.D.; Black, C.; Chen, C.Y.; Reider, P.J.; Efficient syntheses of 2-(3 ',5 '-difluorophenyl)-3-(4 '-methylsulfonylphenyl)-cyclopent-2-enone, a potent COX-2 inhibitor. Tetrahedron 1999, 55, 19, 6001. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 19262 | 1-[4-(methylsulfanyl)phenyl]-1-ethanone；4'-Methylthioacetophenon；4’-(methylthio)acetophenone | 1778-09-2 | C9H10OS | 详情 | 详情 |
| (II) | 31619 | 4-methyl-N'-[(E)-1-[4-(methylsulfanyl)phenyl]ethylidene]benzenesulfonohydrazide | C16H18N2O2S2 | 详情 | 详情 | |
| (III) | 31620 | chloro[1-[4-(methylsulfanyl)phenyl]vinyl]magnesium | C9H9ClMgS | 详情 | 详情 | |
| (IV) | 31621 | 3,5-difluorobenzaldehyde | 32085-88-4 | C7H4F2O | 详情 | 详情 |
| (V) | 31622 | 1-(3,5-difluorophenyl)-2-[4-(methylsulfanyl)phenyl]-2-propen-1-ol | C16H14F2OS | 详情 | 详情 | |
| (VI) | 31623 | (Z)-5-(3,5-difluorophenyl)-4-[4-(methylsulfanyl)phenyl]-4-pentenoic acid | C18H16F2O2S | 详情 | 详情 | |
| (VII) | 25955 | 2-(3,5-difluorophenyl)-3-[4-(methylsulfanyl)phenyl]-2-cyclopenten-1-one | C18H14F2OS | 详情 | 详情 |
合成路线5
The alkylation of dimethyl malonate (IX) with 4-(methylsulfonyl)phenacyl bromide (VIII) by means of K2CO3 in hot acetone gives the substituted malonic ester (X), which is condensed with 2-(3,5-difluorophenyl)acetyl chloride (XI) by means of MgBr2 and pyridine in acetonitrile yielding the disubstituted malonic ester (XII). The cyclization of (XII) by means of triethylamine affords the cylopentenone dicarboxylic ester (XIII), which is finally decarboxylated with H2SO4 in hot acetic acid to provide the target compound.
| 【1】 Grabowski, E.J.J.; Zhaol, D.L.; Prasit, P.; Xu, F.; Ouimet, N.; Tillyer, R.D.; Black, C.; Chen, C.Y.; Reider, P.J.; Efficient syntheses of 2-(3 ',5 '-difluorophenyl)-3-(4 '-methylsulfonylphenyl)-cyclopent-2-enone, a potent COX-2 inhibitor. Tetrahedron 1999, 55, 19, 6001. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VIII) | 19624 | (4R,5S,6S,7R)-4,7-dibenzyl-1,3-bis(3-iodobenzyl)-5,6-bis(methoxymethoxy)-1,3-diazepan-2-one | C37H40I2N2O5 | 详情 | 详情 | |
| (IX) | 19373 | dimethyl malonate；Methyl malonate;Propanedioic acid dimethyl ester | 108-59-8 | C5H8O4 | 详情 | 详情 |
| (X) | 31626 | dimethyl 2-[2-[4-(methylsulfonyl)phenyl]-2-oxoethyl]malonate | C14H16O7S | 详情 | 详情 | |
| (XI) | 28362 | 2-(3,5-difluorophenyl)acetyl chloride | C8H5ClF2O | 详情 | 详情 | |
| (XII) | 31624 | dimethyl 2-[2-(3,5-difluorophenyl)acetyl]-2-[2-[4-(methylsulfonyl)phenyl]-2-oxoethyl]malonate | C22H20F2O8S | 详情 | 详情 | |
| (XIII) | 31625 | dimethyl 3-(3,5-difluorophenyl)-4-[4-(methylsulfonyl)phenyl]-2-oxo-3-cyclopentene-1,1-dicarboxylate | C22H18F2O7S | 详情 | 详情 |