Batabulin sodium, T-67(free acid), Tl-138067(free acid), TL-138067(free acid), T-138067(free acid), -Drug Synthesis Database

【结构式】

【药物名称】Batabulin sodium, T-67(free acid), Tl-138067(free acid), TL-138067(free acid), T-138067(free acid)

【化学名称】2,3,4,5,6-Pentafluoro-N-(3-fluoro-4-methoxyphenyl)benzenesulfonamide sodium salt

【CA登记号】195533-98-3, 195533-53-0 (free acid), 195533-97-2 (K salt), 202998-72-9 (tritium labeled)

【分子式】C₁₃H₆F₆NNaO₃S

【分子量】393.24187

【开发单位】Tularik (Originator)

【药理作用】Brain Cancer Therapy, Breast Cancer Therapy, Colorectal Cancer Therapy, Liver Cancer Therapy, Lung Cancer Therapy, Non-Small Cell Lung Cancer Therapy, Oncolytic Drugs, Antimitotic Drugs, Microtubule-Stabilizing Agents

合成路线1

By condensation of pentafluorophenylsulfonyl chloride (I) with 3-fluoro-4-methoxyaniline (II) in pyridine.

参考文献中间体

【1】 Rosen, T.; Medina, J.C.; Flygare, J.; Shan, B.; Clark, D. (Tularik Inc.); Pentafluorobenzenesulfonamides and analogs. EP 0896533; JP 2000505459; US 5880151; WO 9730677 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	20482	2,3,4,5,6-pentafluorobenzenesulfonyl chloride	832-53-1	C₆ClF₅O₂S	详情	详情
(II)	20483	3-fluoro-4-methoxyphenylamine; 3-fluoro-4-methoxyaniline	366-99-4	C₇H₈FNO	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)