N276-15, -Drug Synthesis Database

【结构式】

【药物名称】N276-15

【化学名称】4-Isopropyl-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-1,4-dihydropyridine-3,5-dicarboxylic acid 5-ethyl 3-[3-(3-pyridyl)propyl] diester

【CA登记号】208194-73-4

【分子式】C₃₄H₃₇N₅O₄

【分子量】579.70509

【开发单位】Nikken Chemicals (Originator)

【药理作用】Modulators of the Therapeutic Activity of Antineoplastic Agents, Multidrug Resistance Modulators, ONCOLYTIC DRUGS

合成路线1

The title dihydropyridine was prepared by Hantzsch synthesis by condensation of aminocrotonate ester (I), isobutyraldehyde (II) and keto ester (III) in boiling isopropanol.

参考文献中间体

【1】 Tasaka, S.; Tanabe, H.; Omori, H.; Kiue, A. (Nikken Chemicals Co., Ltd.); 1,4-Dihydropyridine derivs.. EP 0943615; JP 1998204061; WO 9823607 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	41326	3-(3-pyridinyl)propyl (E)-3-amino-2-butenoate		C₁₂H₁₆N₂O₂	详情	详情
(II)	13226	2-Methylpropanal; Isobutyraldehyde	78-84-2	C₄H₈O	详情	详情
(III)	41327	ethyl 3-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-3-oxopropanoate		C₁₈H₁₇N₃O₃	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)