【结 构 式】 |
【药物名称】KUL-1248 【化学名称】(-)-2-[7(S)-[2(R)-Hydroxy-2-(4-hydroxyphenyl)ethylamino]-5,6,7,8-tetrahydro-2-naphthyloxy]-N,N-dimethylacetamide hydrochloride monohydrate 【CA登记号】 【 分 子 式 】C22H31ClN2O5 【 分 子 量 】438.95577 |
【开发单位】Kissei (Originator) 【药理作用】RENAL-UROLOGIC DRUGS, Treatment of Renal Diseases, Urethral Colic, Agents for, Urolithiasis, Agents for, beta2-Adrenoceptor Agonists, beta3-Adrenoceptor Agonists |
合成路线1
(R)-4-Hydroxymandelic acid (I) was protected as the benzyl ether (II) by treatment with benzyl bromide and K2CO3. Hydroxy acid (II) was then coupled with (S)-2-amino-7-hydroxytetralin (III) by means of BOP reagent to afford hydroxy amide (IV), which was subsequently reduced to amino alcohol (V) using borane-dimethyl sulfide complex. After protection of the aliphatic alcohol group of (V) with trifluoroacetic anhydride, the phenolic hydroxyl was alkylated with 2-bromo-N,N-dimethylacetamide in the presence of Cs2CO3 to furnish adduct (VII). Further deprotection of the trifluoroacetate ester of (VII) employing diethylamine yielded alcohol (VIII). Finally, hydrogenolysis of the benzyl ether (VIII) over Pd/C provided the title compound, which was isolated as the hydrochloride salt.
【1】 Kitazawa, M.; Okazaki, K.; Tamai, T.; Saito, M.; Muranaka, H.; Tanaka, N.; Kobayashi, H.; Kikuchi, K. (Kissei Pharmaceutical Co., Ltd.); Phenylethanolaminotetralincarboxamide derivs.. EP 0893432; US 6046192; WO 9738970 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 31684 | (2R)-4-Hydroxymandelic acid; (2R)-2-Hydroxy-2-(4-hydroxyphenyl)ethanoic acid | 7198-10-9 | C8H8O4 | 详情 | 详情 |
(II) | 31685 | (2R)-2-[4-(benzyloxy)phenyl]-2-hydroxyethanoic acid; (2R)-4-benzyloxymandelic acid | C15H14O4 | 详情 | 详情 | |
(III) | 32819 | (7S)-7-amino-5,6,7,8-tetrahydro-2-naphthalenol | C10H13NO | 详情 | 详情 | |
(V) | 44934 | (2R)-2-[4-(benzyloxy)phenyl]-2-hydroxy-N-[(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]ethanamide | C25H25NO4 | 详情 | 详情 | |
(VI) | 44935 | (7S)-7-([(2R)-2-[4-(benzyloxy)phenyl]-2-hydroxyethyl]amino)-5,6,7,8-tetrahydro-2-naphthalenol | C25H27NO3 | 详情 | 详情 | |
(VII) | 44936 | (1R)-1-[4-(benzyloxy)phenyl]-2-([(2S)-7-[2-(dimethylamino)-2-oxoethoxy]-1,2,3,4-tetrahydro-2-naphthalenyl]amino)ethyl 2,2,2-trifluoroacetate | C31H33F3N2O5 | 详情 | 详情 | |
(VIII) | 44937 | 2-[[(7S)-7-([(2R)-2-[4-(benzyloxy)phenyl]-2-hydroxyethyl]amino)-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-N,N-dimethylacetamide | C29H34N2O4 | 详情 | 详情 |