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【结 构 式】 
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【药物名称】 【化学名称】 【CA登记号】 【 分 子 式 】C28H30N6O2 【 分 子 量 】482.5903 |
【开发单位】 【药理作用】0 |
合成路线1
Treatment of 7-oxo-7H-benzo[e]perimidine-4-carboxylic acid (I) with carbonyldiimidazole produced the corresponding acyl imidazolide (II). Reaction of this intermediate with 1,2-cyclohexanediamine (III) in DMF at 50 C afforded a mixture of amide (IV) and the title hexacyclic compound (V), which were separated by means of preparative HPLC. Alternatively, imidazolide (II) was first coupled with one equivalent of diamine (III) in DMF at r.t. to give amide (IV), which was then converted into the title compound by treatment with an excess of diamine (III) at 50 C.
| 【1】 Dhanoa, D.S.; Luthin, D.R.; May, J.M.; Rabinovich, A.K.; Youngblood, K.L.; Bhumralkar, D.R.; Bychowski, R.A.; Synthesis and biological activity of oxo-7H-benzo[. Bioorg Med Chem Lett 1999, 9, 5, 765. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23786 | 7-oxo-7H-benzo[e]perimidine-4-carboxylic acid | 65359-16-2 | C16H8N2O3 | 详情 | 详情 |
| (II) | 23787 | 4-(1H-imidazol-1-ylcarbonyl)-7H-benzo[e]perimidin-7-one | C19H10N4O2 | 详情 | 详情 | |
| (III) | 23788 | (1S,2S)-2-aminocyclohexylamine; (1S,2S)-1,2-cyclohexanediamine | 21436-03-3 | C6H14N2 | 详情 | 详情 |
| (IV) | 23789 | N-[(1S,2S)-2-aminocyclohexyl]-7-oxo-7H-benzo[e]perimidine-4-carboxamide | C22H20N4O2 | 详情 | 详情 | |
| (V) | 23790 | (9aR,13aR)-N-[(1S,2S)-2-aminocyclohexyl]-15-oxo-9a,10,11,12,13,13a,14,15-octahydro-9H-benzo[7,8]quinazolino[5,4-ab]phenazine-8-carboxamide | C28H30N6O2 | 详情 | 详情 |
Extended Information