|
【结 构 式】 
|
【药物名称】 【化学名称】3-(3-Hydroxy-4-methoxyphenyl)-2-methyl-1-(3,4,5- trimethoxyphenyl)-2(E)-propen-1-one 【CA登记号】 【 分 子 式 】C20H22O6 【 分 子 量 】358.39474 |
【开发单位】Univ. Manchester Inst. Sci. Technol., Manchester (GB); Paterson Inst. Cancer Res., Manchester (GB) 【药理作用】ONCOLYTIC DRUGS, MISCELLANEOUS ANTINEOPLASTIC AGENTS |
合成路线1
Addition of ethylmagnesium bromide to 3,4,5-trimethoxybenzaldehyde (I) gave secondary alcohol (II), which was converted into ketone (III) by Swern oxidation with DMSO and oxalyl chloride. Piperidinium acetate-catalyzed aldol condensation of propiophenone (III) with 3-hydroxy-4-methoxybenzaldehyde (IV), with water removal over 4 Å molecular sieves, gave the corresponding chalcone, obtained as a mixture of geometric isomers, from which the major E-isomer was separated by column chromatography.
| 【1】 Ducki, S.; Forrest, R.; Hadfield, J.A.; Kendall, A.; Lawrence, N.J.; McGown, A.T.; Rennison, D.; Potent antimitotic and cell growth inhibitory properties of substituted chalcones. Bioorg Med Chem Lett 1998, 8, 9, 1051. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11136 | 3,4,5-Trimethoxybenzaldehyde | 86-81-7 | C10H12O4 | 详情 | 详情 |
| (II) | 18453 | 1-(3,4,5-trimethoxyphenyl)-1-propanol | C12H18O4 | 详情 | 详情 | |
| (III) | 18454 | 1-(3,4,5-trimethoxyphenyl)-1-propanone | C12H16O4 | 详情 | 详情 | |
| (IV) | 18455 | 3-hydroxy-4-methoxybenzaldehyde; Isovanillin | 621-59-0 | C8H8O3 | 详情 | 详情 |