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【结 构 式】 
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【药物名称】RP-23618 【化学名称】N,N-Dimethyl-10-[3-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propyl]-10H-phenothiazine-2-sulfonamide 【CA登记号】 【 分 子 式 】C30H35N5O3S2 【 分 子 量 】577.77315 |
【开发单位】Rh?ne-Poulenc Rorer 【药理作用】RESPIRATORY DRUGS, ASTHMA THERAPY |
合成路线1
Alkylation of phenothiazine (I) with 1-bromo-3-chloropropane (II) in the presence of NaH in DMF at room temperature afforded chloropropyl compound (III), and then reaction of this compound with 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (IV) and K2CO3 in refluxing dioxan yielded the title compound.
| 【1】 Bright, C.; Brown, T.J.; Cox, P.; Halley, F.; Lockey, P.; McLay,, I.M.; Moore, U.; Porter, B.; Williams, R.J.; Identification of a non peptidic RANTES antagonist. Bioorg Med Chem Lett 1998, 8, 7, 771-774. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18114 | N,N-dimethyl-10H-phenothiazine-2-sulfonamide | 1090-78-4 | C14H14N2O2S2 | 详情 | 详情 |
| (II) | 10358 | 1-Bromo-3-chloropropane | 109-70-6 | C3H6BrCl | 详情 | 详情 |
| (III) | 18115 | 10-(3-chloropropyl)-N,N-dimethyl-10H-phenothiazine-2-sulfonamide | C17H19ClN2O2S2 | 详情 | 详情 | |
| (IV) | 18116 | 1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-one | 1021-25-6 | C13H17N3O | 详情 | 详情 |
Extended Information