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【结 构 式】 
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【药物名称】DA-3797 【化学名称】 【CA登记号】 【 分 子 式 】C34H35N5O5 【 分 子 量 】593.68855 |
【开发单位】Daiichi Pharm 【药理作用】0 |
合成路线1
2-Benzyloxyaniline (I) was acylated with N-tert-butoxycarbonyl glycine (II) by means of 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide.HCl (EDC) to give amide (III). Alkylation with bromoacetamide (IV) in the presence of NaH in THF provided (V), and then removal of the Boc protecting group with trifluoroacetic acid gave amine (VI). This amine was condensed with 3-tolyl isocyanate (VII) to give the phenylurea (VIII). Cleavage of the benzyl group by hydrogenolysis on Pd/C provided phenol (IX), which was alkylated with methyl bromoacetate in the presence of K2CO3 to give ether (X). Alkaline hydrolysis of the ester group gave acid (XI), which was finally condensed with N-methylaniline (XII) by means of EDC to yield the target compound.
| 【1】 Takeda, Y.; et al.; Synthesis of phenoxyacetic acid derivatives as highly potent antagonists of gastrin/cholecystokinin-B receptors. Chem Pharm Bull 1998, 46, 3, 434-444. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18065 | 2-(benzyloxy)aniline; 2-(benzyloxy)phenylamine | C13H13NO | 详情 | 详情 | |
| (II) | 18066 | N-alpha-t-BOC-glycine; 2-[(tert-butoxycarbonyl)amino]acetic acid | 4530-20-5 | C7H13NO4 | 详情 | 详情 |
| (III) | 18067 | tert-butyl 2-[2-(benzyloxy)anilino]-2-oxoethylcarbamate | C20H24N2O4 | 详情 | 详情 | |
| (IV) | 18068 | 2-bromo-N-methyl-N-phenylacetamide | C9H10BrNO | 详情 | 详情 | |
| (V) | 18069 | tert-butyl 2-[2-(benzyloxy)[2-(methylanilino)-2-oxoethyl]anilino]-2-oxoethylcarbamate | C29H33N3O5 | 详情 | 详情 | |
| (VI) | 18070 | 2-amino-N-[2-(benzyloxy)phenyl]-N-[2-(methylanilino)-2-oxoethyl]acetamide | C24H25N3O3 | 详情 | 详情 | |
| (VII) | 18071 | m-Tolyl Isocyanate; 1-isocyanato-3-methylbenzene; 3-methylphenyl isocyanate | 621-29-4 | C8H7NO | 详情 | 详情 |
| (VIII) | 18072 | 2-(2-(benzyloxy)[2-[(3-toluidinocarbonyl)amino]acetyl]anilino)-N-methyl-N-phenylacetamide | C32H32N4O4 | 详情 | 详情 | |
| (IX) | 18073 | 2-(2-hydroxy[2-[(3-toluidinocarbonyl)amino]acetyl]anilino)-N-methyl-N-phenylacetamide | C25H26N4O4 | 详情 | 详情 | |
| (X) | 18074 | methyl 2-[2-([2-(methylanilino)-2-oxoethyl][2-[(3-toluidinocarbonyl)amino]acetyl]amino)phenoxy]acetate | C28H30N4O6 | 详情 | 详情 | |
| (XI) | 18075 | 2-[2-([2-(methylanilino)-2-oxoethyl][2-[(3-toluidinocarbonyl)amino]acetyl]amino)phenoxy]acetic acid | C27H28N4O6 | 详情 | 详情 | |
| (XII) | 10409 | N-Methyl-N-phenylamine; N-methylaniline; Monomethylaniline | 100-61-8 | C7H9N | 详情 | 详情 |