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【结 构 式】 
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【药物名称】 【化学名称】6-(3-Fluorophenyl)-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]-quinolin-8-one 【CA登记号】 【 分 子 式 】C16H12FNO3 【 分 子 量 】285.27734 |
【开发单位】China Medical College (Originator), National Cancer Institute (Originator), University of North Carolina (Originator) 【药理作用】ONCOLYTIC DRUGS, ANTIMITOTIC DRUGS |
合成路线1
The compound was prepared by condensation of acetophenone (I) with 3-flourobenzaldehyde (II) in refluxing ethanolic NaOH, followed by cyclization of the intermediate chalcone in diphenyl ether at 180 C.
| 【1】 Xia, Y.; et al.; Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3, 4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents. J Med Chem 1998, 41, 7, 1155. |
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