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【结 构 式】 
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【药物名称】 【化学名称】Sulfamic acid 3,4-dimethyl-2-oxo-2H-1-benzopyran-7-yl ester 【CA登记号】 【 分 子 式 】C11H11NO5S 【 分 子 量 】269.27802 |
【开发单位】University of Bath (Originator) 【药理作用】ONCOLYTIC DRUGS, HORMONAL AGENTS |
合成路线1
Pechmann condensation of resorcinol (I) with ethyl 2-methylacetylacetate (II) in concentrated sulfuric acid at room temperature provided coumarine (III). Further treatment with one equivalent of sodium hydride and an excess of sulfamoyl chloride yielded the target sulfamate.
| 【1】 Woo, L.W.C.; et al.; Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase. J Med Chem 1998, 41, 7, 1068. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10361 | 1,3-Dihydroxybenzene; m-Dihydroxybenzene; Resorcinol; Resorcin; 1,3-Benzenediol | 108-46-3 | C6H6O2 | 详情 | 详情 |
| (II) | 10362 | ethyl 2-methyl-3-oxobutanoate; ethyl 2-methylacetoacetate | 609-14-3 | C7H12O3 | 详情 | 详情 |
| (III) | 10360 | 3,4-Dimethylumbelliferone; 7-Hydroxy-3,4-dimethyl-2H-chromen-2-one | 2107-78-0 | C11H10O3 | 详情 | 详情 |
Extended Information