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【结 构 式】 
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【药物名称】PP1D-1 【化学名称】N-(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)succinamic acid methyl ester 【CA登记号】175090-76-3 【 分 子 式 】C15H12ClNO5 【 分 子 量 】321.71959 |
【开发单位】China Medical College (Originator), National Taiwan University (Originator) 【药理作用】Anticoagulants, Antiplatelet Therapy, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, Non-Steroidal Antiinflammatory Drugs |
合成路线1
Title compound was obtained by acylation of 2-amino-3-chloro-1,4-naphthoquinone (I) with 3-carbomethoxypropionyl chloride (II) in the presence of dry HCl in refluxing toluene.
| 【1】 Kuo, S.-C.; et al.; Synthesis and cytotoxicity of 1,2-disubstituted naphth[2,3-d]imidazole-4,9-diones and related compounds. J Med Chem 1996, 39, 7, 1447-1451. |
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