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【结 构 式】 
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【药物名称】PIQ-22 【化学名称】2-(2,6-Diethylphenyl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione 【CA登记号】202200-23-5 【 分 子 式 】C19H19NO2 【 分 子 量 】293.36878 |
【开发单位】Ishihara Sangyo (Originator) 【药理作用】ONCOLYTIC DRUGS, Angiogenesis Inhibitors, Membrane Alanine Aminopeptidase (Aminopeptidase N) Inhibitors |
合成路线1
The target product can be obtained by reaction of homophthalic anhydride (I) with amine (II) at high temperature (160-180 C).
| 【1】 Miyachi, H.; et al.; Novel potent nonpeptide aminopeptidase N inhibitors with a cyclic imide skeleton. J Med Chem 1998, 41, 3, 263. |
Extended Information