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【结 构 式】 
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【药物名称】ADAM-II 【化学名称】6,6-Bis[3-chloro-4-methoxy-5-(methoxycarbonyl)phenyl]-5-hexenoic acid methyl ester 【CA登记号】 【 分 子 式 】C25H26Cl2O8 【 分 子 量 】525.38717 |
【开发单位】National Cancer Institute (Originator), Purdue University (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Reverse Transcriptase Inhibitors |
合成路线1
Title compound was prepared by Wittig condensation of benzophenone (I) with the phosphorane derived from (4-methoxycarbonylbutyl)triphenyl phosphonium bromide (II) and sodium hexamethyldisilazide at -78 C.
| 【1】 Hejchman, E.; Casimiro-Garcia, A.; Cushman, M.; et al.; New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors. J Med Chem 1998, 41, 12, 2076. |
| 【2】 Rice, W.G.; Casimiro-Garcia, A.; Cushman, M.S. (Purdue Research Foundation; US Department of Health & Human Services); Alkenyldiarylmethane non-nucleoside HIV-1 reverse transcriptase inhibitors. WO 9936384 . |
Extended Information