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【结 构 式】 
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【药物名称】DBO-83 【化学名称】3-Chloro-6-(3,8-diazabicyclo[3.2.1]oct-3-yl)pyridazine dihydrochloride 【CA登记号】195211-53-1 【 分 子 式 】C10H15Cl3N4 【 分 子 量 】297.61685 |
【开发单位】Università degli Studi di Firenze (Originator), Università degli Studi di Milano (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, Non-Opioid Analgesics, Nicotinic Receptor Agonists |
合成路线1
3-Benzyl-3,8-diazabicyclo[3.2.1]octane (I) was protected at the N8 position with di tert-butyl dicarbonate in CH2Cl2, and carbamate (II) was then debenzylated by catalytic hydrogenolysis over Pd/C. The resulting bicyclic amine (III) was condensed with 3,6-dichloropyridazine (IV) in the presence of Et3N to give the Boc-protected intermediate (V), which was finally deprotected with HCl in Et2O.
| 【1】 Barlocco, D.; Tondi, D.; Cignarella, G.; et al.; Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: Synthesis, activity, and modeling. J Med Chem 1998, 41, 5, 674. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25765 | 3-benzyl-3,8-diazabicyclo[3.2.1]octane | C13H18N2 | 详情 | 详情 | |
| (II) | 25766 | tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate | C18H26N2O2 | 详情 | 详情 | |
| (III) | 25767 | tert-butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate | C11H20N2O2 | 详情 | 详情 | |
| (IV) | 11292 | 3,6-Dichloropyridazine | 141-30-0 | C4H2Cl2N2 | 详情 | 详情 |
| (V) | 25768 | tert-butyl 3-(6-chloro-3-pyridazinyl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate | C15H21ClN4O2 | 详情 | 详情 |