BMOV, -Drug Synthesis Database

【结构式】

【药物名称】BMOV

【化学名称】Bis(maltolato)oxovanadium(IV)

【CA登记号】

【分子式】C₁₂H₁₀O₇V

【分子量】317.1513

【开发单位】Kinetek (Originator), University of British Columbia (Originator), Gho Pharma (Not Determined)

【药理作用】DERMATOLOGIC DRUGS, Wound-Healing Agents

合成路线1

Bis(maltolato)oxovanadium(IV) is prepared by complexation of maltol (I) with vanadyl sulfate in refluxing aqueous solution, adjusting the pH at approx. 8.5 with KOH.

参考文献中间体

【1】 McNeill, J.H.; et al.; Bis(maltolato)oxovanadium(IV) is a potent insulin mimic. J Med Chem 1992, 35, 8, 1489.
【2】 Orvig, C.; et al.; Reaction chemistry of BMOV, bis(maltolato) oxovanadium(IV), a potent insulin mimetic agent. J Am Chem Soc 1995, 117, 51, 12759.
【3】 McNeill, J.H.; Hoveyda, H.R.; Orvig, C. (University of British Columbia); Complexed vanadium for the treatment of diabetes mellitus. JP 1994511244; US 5300496; WO 9306811 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	13671	Hydroxymethylpyrone; 3-Hydroxy-2-methyl-4H-pyran-4-one；Maltol;3-Hydroxy-2-methyl-4-pyrone	118-71-8	C₆H₆O₃	详情	详情

Extended Information