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【结 构 式】 
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【药物名称】Estrone 3-oleate, Oleoyl-estrone 【化学名称】3-Oleoylestra-1,3,5(10)trien-17-one 【CA登记号】180003-17-2 【 分 子 式 】C36H54O3 【 分 子 量 】534.82998 |
【开发单位】Oleoyl-Estrone Developments (Proprietary), Salvat (Originator), Manhatan Pharmaceuticals (Licensee) 【药理作用】Antiobesity Drugs, METABOLIC DRUGS, Treatment of Nutritional Disorders |
合成路线1
Oleoyl-estrone can be obtained by direct condensation of commercially available estrone (I) and oleoyl chloride (II) in anhydrous pyridine at 40 C.
| 【1】 Sanchis, D.; Balada, F.; Picó, C.; Grasa, M.M.; Virgili, J.; Farrerons, C.; Palou, A.; Fernández-López, J.A.; Remesar, X.; Alemany, M.; Rats receiving the slimming agent oleoyl-estrone in liposomes (Merlin-2) decrease food intake but maintain thermogenesis. Arch Physiol Biochem 1997, 105, 7, 663. |
| 【2】 del Fresno, M.; Cullell-Young, M.; Oleoyl-Estrone. Drugs Fut 2002, 27, 7, 648. |
| 【3】 Alemany, M. (Laboratorios Salvat SA); Fatty-acid monoesters of estrogens for the treatment of obesity and/or overweight. EP 0771817; US 5798348 . |
Extended Information