【结 构 式】 |
【药物名称】KF-24705 【化学名称】1-[2-(Hydroxymethyl)-6,11-dihydrodibenzo[b,e]oxepin-11-yl]-4-phenylpiperidin-4-ol 【CA登记号】188607-29-6 【 分 子 式 】C26H27NO3 【 分 子 量 】401.50999 |
【开发单位】Kyowa Hakko (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Non-Opioid Analgesics |
合成路线1
Hydroxy dibenzooxepine (I) was converted to the corresponding chloride (II) by treatment with SOCl2 in CH2Cl2. Condensation of (II) with 4-hydroxy-4-phenylpiperidine (III) produced adduct (IV). The carboxylate group of (IV) was then reduced by means of LiAlH4 in cold THF to furnish the title alcohol.
【1】 Kumazawa, T.; Koshimura, H.; Aono, S.; Ichikawa, S.; Kitamura, S. (Kyowa Hakko Kogyo Co., Ltd.); Phenylpiperidine derivs.. EP 0974583; WO 9710213 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 41323 | methyl 11-hydroxy-6,11-dihydrodibenzo[b,e]oxepine-2-carboxylate | C16H14O4 | 详情 | 详情 | |
(II) | 41324 | methyl 11-chloro-6,11-dihydrodibenzo[b,e]oxepine-2-carboxylate | C16H13ClO3 | 详情 | 详情 | |
(III) | 28021 | 4-phenyl-4-piperidinol; 4-Hydroxy-4-phenylpiperidine; 4-(4-Phenyl)-4-hydroxypiperidine | 40807-61-2 | C11H15NO | 详情 | 详情 |
(IV) | 41325 | methyl 11-(4-hydroxy-4-phenyl-1-piperidinyl)-6,11-dihydrodibenzo[b,e]oxepine-2-carboxylate | C27H27NO4 | 详情 | 详情 |
Extended Information