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【结 构 式】 
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【药物名称】RL-3142 【化学名称】3-[4-(Dimethylamino)phenyl]-1-[4-(1-imidazolyl)phenyl]-2(E)-propenone 【CA登记号】 【 分 子 式 】C20H19N3O 【 分 子 量 】317.39393 |
【开发单位】University of California, Oakland (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antimalarials, Treatment of Protozoal Diseases |
合成路线1
The compound is prepared by aldol condensation between 4-dimethylaminobenzaldehyde (I) and imidazolyl acetophenone (II) in the presence of NaOH in methanol.
| 【1】 Cohen, F.E.; McKerrow, J.H.; Kenyon, G.L.; Li, Z.; Chen, X.; Gong, B.; Li, R. (University of California, Oakland); Inhibitors of metazoan parasite proteases. WO 9630004 . |
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