RSD-992, -Drug Synthesis Database

【结构式】

【药物名称】RSD-992

【化学名称】1-(4-Methylpiperazin-1-yl)-2-(2-naphthyl)ethanone hydrochloride

【CA登记号】219901-21-0, 219901-24-3 (free base)

【分子式】C₁₇H₂₁ClN₂O

【分子量】304.82272

【开发单位】Cardiome (Originator), Xoma (Not Determined)

【药理作用】Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS, RENAL-UROLOGIC DRUGS, Treatment of Erectile Dysfunction, Treatment of Male Sexual Dysfunction, 5-HT2C (5-HT1C) Agonists, Sodium Channel Blockers

合成路线1

2-(2-Naphthyl)acetic acid (I) is activated as the corresponding acid chloride (II) upon refluxing with SOCl2. Subsequent condensation of acid chloride (II) with N-methyl piperazine (III) affords the title amide.

参考文献中间体

【1】 Hayes, E.S. (Cardiome Pharma Corp.); Serotonin ligands as pro-erectile cpds.. WO 0028993 .
【2】 Zolotoy, A.B.; Hayes, E.S. (Cardiome Pharma Corp.); Aroylpiperazines for modulating sexual activity. WO 9902159 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	50657	2-Naphthylacetic acid; beta-Naphthylacetic acid	581-96-4	C₁₂H₁₀O₂	详情	详情
(II)	13970	2-(2-Naphthyl)acetyl chloride		C₁₂H₉ClO	详情	详情
(III)	10061	1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine	109-01-3	C₅H₁₂N₂	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)