|
【结 构 式】 
|
【药物名称】Ciproxifan, FUB-359 【化学名称】Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxy]phenyl]methanone 【CA登记号】184025-18-1, 184025-19-2 (monomaleate) 【 分 子 式 】C16H18N2O2 【 分 子 量 】270.33406 |
【开发单位】Bioprojet (Originator), INSERM (Originator) 【药理作用】Antiepileptic Drugs, Antipsychotic Drugs, Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, PSYCHOPHARMACOLOGIC DRUGS, Histamine H3 Receptor Antagonists |
合成路线1
This compound can be obtained by two similar ways: 1) The hydrogenation of the double bond of 3-(4-imidazolyl)propenoic acid (I) with H2 over Pd/C in water gives the propionic acid (II), which is esterified with ethanol and sulfuric acid to the ethyl ester (III). The protection of (III) with triphenylmethyl chloride by means of triethylamine in DMF affords the trityl derivative (IV), which is reduced with LiAlH4 in THF yielding 3-(4-imidazolyl)propanol (V). The condensation of (V) with the phenol (VI) by means of triphenylphosphine and diethyl azodicarboxylate in THF provides the ether (VII), which deprotected with HCl in hot THF. 2) Alternatively, propanol (V) can be condensed with cyclopropyl 4-fluorophenyl ketone (VIII) by means of NaH in refluxing toluene to give the previously reported ether (VII).
| 【1】 Krause, M.; Stark, H.; Sadek, B.; et al.; Novel histamine H3-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy) propyl)-1H-imidazole structures like ciproxifan and related compounds. J Med Chem 2000, 43, 21, 3987. |
| 【2】 Ligneau, X.; Stark, H.; Elz, S.; Teriuk, W.; Schwartz, J.-C.; Athmani, S.; Arrang, J.-M.; Hüls, A.; Schunack, W.; Ganellin, C.R.; Optimization of 4-(3-(phenoxy)propyl)-1H-imidazoles leading to ciproxifan, a novel potent histamine H3-receptor antagonist. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.120. |
| 【3】 Imidazole derivs. as histamine receptor H3 (ant)agonists. EP 0760811; FR 2732017; JP 1998501001; WO 9629315 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VIIII) | 27427 | cyclopropyl(4-fluorophenyl)methanone | 772-31-6 | C10H9FO | 详情 | 详情 |
| (I) | 27420 | Urocanic acid; (E)-3-(1H-imidazol-4-yl)-2-propenoic acid | 104-98-3 | C6H6N2O2 | 详情 | 详情 |
| (II) | 27421 | 3-(1H-imidazol-4-yl)propionic acid | C6H8N2O2 | 详情 | 详情 | |
| (III) | 27422 | ethyl 3-(1H-imidazol-4-yl)propanoate | C8H12N2O2 | 详情 | 详情 | |
| (IV) | 27423 | ethyl 3-(1-trityl-1H-imidazol-4-yl)propanoate | C27H26N2O2 | 详情 | 详情 | |
| (V) | 27424 | 3-(1-trityl-1H-imidazol-4-yl)-1-propanol | C25H24N2O | 详情 | 详情 | |
| (VI) | 27425 | cyclopropyl(4-hydroxyphenyl)methanone | C10H10O2 | 详情 | 详情 | |
| (VII) | 27426 | cyclopropyl[4-[3-(1-trityl-1H-imidazol-4-yl)propoxy]phenyl]methanone | C35H32N2O2 | 详情 | 详情 |