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【结 构 式】 
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【药物名称】NBI-27914 【化学名称】N-[5-Chloro-2-methyl-6-(2,4,6-trichlorophenylamino)pyrimidin-4-yl]-N-(cyclopropylmethyl)-N-propylamine 【CA登记号】184241-44-9 【 分 子 式 】C18H20Cl4N4 【 分 子 量 】434.1989 |
【开发单位】Neurocrine Biosciences (Originator) 【药理作用】Cerebrovascular Diseases, Treatment of, GASTROINTESTINAL DRUGS, Irritable Bowel Syndrome, Agents for, NEUROLOGIC DRUGS, Stroke, Treatment of, CRF1 Antagonists |
合成路线1
The condensation of 4,6-dichloro-2-methylpyrimidine (I) with 2,4,6-trichloroaniline (II) by means of NaH in THF gives N-(6-chloro-2-methylpyrimidin-4-yl)-N-(2,4,6-trichlorophenyl)amine (III), which is condensed with N-(cyclopropylmethyl)-N-propylamine (IV) by heating at 100-190 C yielding N-(cyclopropylmethyl)-N-[2-methyl-6-(2,4,6-trichlorophenylamino)-pyrimidin-4-yl]-N-propylamine (V). Finally, this compound is chlorinated with N-chlorosuccinimide (NCS) in refluxing chloroform.
| 【1】 Dagnino, R. jr.; Chen, C.; de Souzza, E.B.; et al.; Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists. J Med Chem 1996, 39, 22, 4360. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 32323 | 4,6-dichloro-2-methylpyrimidine | 1780-26-3 | C5H4Cl2N2 | 详情 | 详情 |
| (II) | 15466 | 2,4,6-Trichloroaniline; 2,4,6-Trichlorophenylamine | 634-93-5 | C6H4Cl3N | 详情 | 详情 |
| (III) | 32324 | N-(6-chloro-2-methyl-4-pyrimidinyl)-N-(2,4,6-trichlorophenyl)amine; 6-chloro-2-methyl-N-(2,4,6-trichlorophenyl)-4-pyrimidinamine | C11H7Cl4N3 | 详情 | 详情 | |
| (IV) | 27745 | N-(cyclopropylmethyl)-1-propanamine | 26389-60-6 | C7H15N | 详情 | 详情 |
| (V) | 32325 | N-(cyclopropylmethyl)-N-[2-methyl-6-(2,4,6-trichloroanilino)-4-pyrimidinyl]-N-propylamine; N(4)-(cyclopropylmethyl)-2-methyl-N(4)-propyl-N(6)-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine | C18H21Cl3N4 | 详情 | 详情 |