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【结 构 式】

【药物名称】YM-49244

【化学名称】1'-[2-[3-(3,4-Dichlorophenyl)-1-[2-[3-(isopropoxy)phenyl]acetyl]piperidin-3-yl]ethyl]-1'-methyl-3-oxospiro[1,2,3,4-tetrahydroisoquinoline-1,4'-piperidinium] iodide

【CA登记号】173941-19-0

【 分 子 式 】C38H46Cl2IN3O3

【 分 子 量 】790.61902

【开发单位】Yamanouchi (Originator)

【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Asthma Therapy, Bronchodilators, Non-Opioid Analgesics, RESPIRATORY DRUGS, Tachykinin NK1 Antagonists

合成路线1

The known piperidinoethanol derivative (I) was converted to the mesylate (II) upon treatment with methanesulfonyl chloride and triethylamine. Displacement of the mesylate group of (II) with the spiro-substituted piperidine (III) provided adduct (IV). Finally, quaternization of piperidine (IV) with iodomethane gave the corresponding ammonium salt as a mixture of cis/trans isomers that were separated by column chromatography.

1 Kubota, H.; Okamoto, Y.; Fujii, M.; Ikeda, K.; Takeuchi, M.; Shibanuma, T.; Isomura, Y.; Synthesis and NK1 receptor antagonistic activity of (±)-1-acyl-3-(3,4-dichlorophenyl)-3-[2-(spiro-substituted piperidin-1'-yl)ethyl]piperidines. Bioorg Med Chem Lett 1998, 8, 12, 1541.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 51324 1-[3-(3,4-dichlorophenyl)-3-(2-hydroxyethyl)-1-piperidinyl]-2-(3-isopropoxyphenyl)-1-ethanone C24H29Cl2NO3 详情 详情
(II) 51325 2-[3-(3,4-dichlorophenyl)-1-[2-(3-isopropoxyphenyl)acetyl]-3-piperidinyl]ethyl methanesulfonate C25H31Cl2NO5S 详情 详情
(III) 25126 1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-piperidin]-3-one C13H16N2O 详情 详情
(IV) 51326   C37H43Cl2N3O3 详情 详情
Extended Information