|
【结 构 式】 
|
【药物名称】EMATE 【化学名称】3-(Sulfamoyloxy)estra-1,3,5(10)-trien-17-one 【CA登记号】148672-09-7 【 分 子 式 】C18H23NO4S 【 分 子 量 】349.45231 |
【开发单位】 【药理作用】Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, ONCOLYTIC DRUGS, Estrogen Agonists, Steryl Sulfatase Inhibitors |
合成路线1
By esterification of estrone (I) with chlosulfonamide (II) and NaH in DMF.
| 【1】 Potter, B.V.L.; Howarth, N.M.; Purohit, A.,; Reed, M.J.; Steroid sulphatase inhibitors: a new endocrine therapy. Drugs Fut 1994, 19, 7, 673. |
| 【2】 Reed, M.J.; Potter, B.V.L.; Purohit, A.,; Howarth, N.M.; Cooper, G.; Duncan, L.J.; Phosphonates and thiophosphonates as sulfate surrogates: Synthesis of estrone 3-methylthiophosphonate a potent inhibitor of estrone sulfatase. Bioorg Med Chem Lett 1993, 3, 2, 313-318. |
Extended Information