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【结 构 式】 
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【药物名称】Omiloxetine hydrochloride 【化学名称】trans-2-[3-(1,3-Benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-1-yl]-1-(4-fluorophenyl)-1-ethanone hydrochloride 【CA登记号】176894-09-0 (free base) 【 分 子 式 】C27H26ClF2NO4 【 分 子 量 】501.96237 |
【开发单位】Ferrer (Originator) 【药理作用】Antidepressants, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS, 5-HT Reuptake Inhibitors |
合成路线1
A further procedure for the synthesis of the title compound has been reported. The compound was prepared by alkylation of paroxetine acetate (I) with 2-chloro-4'-fluoroacetophenone (II) in the presence of NaHCO3 in refluxing EtOH, followed by conversion to the hydrochloride salt with HCl in Et2O.
| 【1】 Sacristan, A.; Ortiz, J.A.; Foguet, R.; Gubert, S. (Ferrer Internacional SA); Process for preparing (-)-trans-N-p-fluorobenzoylmethyl-4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]piperidine. US 5973155; WO 9731915 . |
Extended Information