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【结 构 式】 
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【药物名称】GW-320659, 1555U88, BW-1555U88 【化学名称】(2S,3S,5R)-2-(3,5-Difluorophenyl)-3,5-dimethylmorpholin-2-ol hydrochloride 【CA登记号】135306-42-2, 135414-64-1 (racemic, (2alpha,3alpha, 5alpha)-isomer) 【 分 子 式 】C12H16ClF2NO2 【 分 子 量 】279.71662 |
【开发单位】GlaxoSmithKline (Originator) 【药理作用】Antiobesity Drugs, Attention Deficit Hyperactivity Disorder (ADHD), Treatment of, METABOLIC DRUGS, PSYCHOPHARMACOLOGIC DRUGS, Treatment of Nutritional Disorders, Dopamine Reuptake Inhibitors, Norepinephrine Reuptake Inhibitors |
合成路线1
3,5-Difluorobenzonitrile (I) was treated with ethylmagnesium bromide to give propiophenone (II), which was subsequently brominated with dioxane dibromide yielding bromoketone (III). Condensation of (III) with (R)-2-amino-1-propanol (IV) in the presence of 2,6-lutidine produced the corresponding amino ketone, which spontaneously cyclized to the title cyclic hemiacetal form.
| 【1】 Kelley, J.L.; et al.; (2S,3S,5R)-2-(3,5-Difluorophenyl)-3, 5-dimethyl-2-morpholinol: A novel antidepressant agent and selective inhibitor of norepinephrine uptake. J Med Chem 1996, 39, 2, 347. |
| 【2】 Kelley, J.L.; Musso, D.L.; Boswell, G.E.; Cooper, B.R. (GlaxoSmithKline plc); Novel morpholinol cpds., their preparation and use. AU 9165639; EP 0426416; JP 1991206084; US 5104870 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 55867 | 3,5-Difluorobenzonitrile; 5-Cyano-1,3-difluorobenzene | 64248-63-1 | C7H3F2N | 详情 | 详情 |
| (II) | 55868 | 3,5-Difluoropropiophenone | 135306-45-5 | C9H8F2O | 详情 | 详情 |
| (III) | 55869 | 2-bromo-1-(3,5-difluorophenyl)-1-propanone | C9H7BrF2O | 详情 | 详情 | |
| (IV) | 21414 | (2R)-2-Amino-1-propanol; D-Alaninol; D-(-)-Alaninol | 35320-23-1 | C3H9NO | 详情 | 详情 |