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【结 构 式】 
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【药物名称】Fandofloxacin hydrochloride, DW-116 【化学名称】6-Fluoro-1-(5-fluoropyridin-2-yl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride 【CA登记号】164150-85-0, 164150-99-6 (free base) 【 分 子 式 】C20H19ClF2N4O3 【 分 子 量 】436.84923 |
【开发单位】Dong-Wha (Originator) 【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY, Quinolones |
合成路线1
Condensation of ethyl 2,4,5-trifluorobenzoylacetate (I) with triethyl orthoformate in refluxing Ac2O produced the benzoyl ethoxyacrylate (II), which was further condensed with 2-amino-5-fluoropyridine (III) to afford enamine (IV). Cyclization of (IV) in the presence of K2CO3 gave rise to the quinolone (V). The 7-fluoride group of (V) was then displaced by N-methylpiperazine (VI) in cold pyridine to furnish the piperazinyl quinolone (VII). Finally, ester hydrolysis in (VII) under acidic conditions yielded the target compound. In a closely related procedure, ester (V) was hydrolyzed to acid (VIII) using HCl. Subsequent displacement of the 7-fluoride of (VIII) with N-methylpiperazine (VI) provided the desired piperazinyl quinolone.
| 【1】 Yoon, S.J.; et al.; Synthesis, pharmacokinetics, and biological activity of a series of new pyridonecarboxylic acid antibacterial agents bearing a 5-fluoro-2-pyridyl group or a 3-fluoro-4-pyridyl group at N-1. J Heterocycl Chem 1997, 34, 3, 1021. |
| 【2】 Skuballa, W.; Buchmann, B.; Heindl, J.; Frohlich, W.; Ekerdt, R.; Giesen, C. (Schering AG); Leukotriene B4 derivs., methods of preparing them and their use as drugs. EP 0741687; JP 1997511487; WO 9520564 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 55875 | Ethyl 2,4,5-trifluorobenzoylacetate | C11H9F3O3 | 详情 | 详情 | |
| (II) | 55876 | ethyl (Z)-3-ethoxy-2-(2,4,5-trifluorobenzoyl)-2-propenoate | C14H13F3O4 | 详情 | 详情 | |
| (III) | 55877 | 5-fluoro-2-pyridinamine; 5-fluoro-2-pyridinylamine | C5H5FN2 | 详情 | 详情 | |
| (IV) | 55878 | ethyl (Z)-3-[(5-fluoro-2-pyridinyl)amino]-2-(2,4,5-trifluorobenzoyl)-2-propenoate | C17H12F4N2O3 | 详情 | 详情 | |
| (V) | 55879 | ethyl 6,7-difluoro-1-(5-fluoro-2-pyridinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylate | C17H11F3N2O3 | 详情 | 详情 | |
| (VI) | 10061 | 1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine | 109-01-3 | C5H12N2 | 详情 | 详情 |
| (VII) | 55880 | ethyl 6-fluoro-1-(5-fluoro-2-pyridinyl)-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylate | C22H22F2N4O3 | 详情 | 详情 | |
| (VIII) | 55881 | 6,7-difluoro-1-(5-fluoro-2-pyridinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C15H7F3N2O3 | 详情 | 详情 |