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【结 构 式】 
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【药物名称】SK-946 【化学名称】N-[2-(1-Azabicyclo[3.3.0]octan-5-yl)ethyl]-2-nitroaniline fumarate 【CA登记号】167889-18-1, 167889-05-6 (free base), 167889-17-0 (monoHCl), 167889-19-2 (monomaleate) 【 分 子 式 】C19H25N3O6 【 分 子 量 】391.4276 |
【开发单位】Sanwa (Originator) 【药理作用】Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, Muscarinic M1 Agonists |
合成路线1
By condensation of 2-chloronitrobenzene (I) with 5-(2-aminoethyl)-1-azabicyclo[3.3.0]octane (II) in refluxing pyridine.
| 【1】 Suzuki, T.; Oka, M.; Maeda, K.; Furusawa, K.; Uesaka, H.; Kataoka, T.; Synthesis and muscarinic activity of novel aniline derivatives with a 1-azabicyclo[3.3.0]octane moiety. Chem Pharm Bull 1999, 47, 1, 28. |
| 【2】 Baba, Y.; Suzuki, T.; Suzuki, T.; Hirooka, K.; Kurono, M.; Sawai, K. (Sanwa Kagaku Kenkyusho Co., Ltd.); 1-Azabicyclo[3.3.0]octane derivs. and their use. EP 0647642; US 5530138 . |
Extended Information