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【结 构 式】 
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【药物名称】NSC-364432, SarCNU 【化学名称】1-(Carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitrosourea 【CA登记号】81965-43-7 【 分 子 式 】C6H11ClN4O3 【 分 子 量 】222.63257 |
【开发单位】National Cancer Institute (Originator) 【药理作用】ONCOLYTIC DRUGS, DNA Alkylating Drugs |
合成路线1
The condensation of N-(2-chloroethyl)-N-nitrosocarbamic acid 4-nitrophenyl ester (I) with sarcosinamide (II) gives the target nitrosourea. Alternatively, the nitrosation of N2-[N-(2-chloroethyl)carbamoyl]sarcosinamide (III) by means of NaNO2 and formic acid also yields the target nitrosourea.
| 【1】 Suami, T.; et al.; (2-Chloroethyl)nitrosourea congeners of amino acid amides. J Med Chem 1982, 25, 7, 829. |
| 【2】 Suami, T.; Nitrosourea derivs.. US 4452814 . |
Extended Information