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【结 构 式】

【药物名称】

【化学名称】2-[6-(4-Amidino-2-fluorobenzamido)-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl]acetic acid trifluoroacetate

【CA登记号】

【 分 子 式 】C22H19F4N3O6

【 分 子 量 】497.40683

【开发单位】Lilly (Originator)

【药理作用】Antiplatelet Therapy, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, Integrin alphaIIbbeta3 (Fibrinogen gpIIb/IIIa) Antagonists

合成路线1

The known amino tetralone (I) was coupled with 4-cyano-2-fluorobenzoic acid (II) in the presence of EDC to give amide (III). Subsequent conversion of the nitrile group of (III) into the required amidine was achieved by the following sequence consisting of addition of SH2, followed by S-methylation to produce the iminothioether (IV), displacement of the methylthio group of (IV) with ammonium acetate, and then protection of the resulting amidine with di-tert-butyl dicarbonate, yielding the Boc-protected amidine (V). Basic hydrolysis of the ethyl ester group of (V) generated the corresponding carboxylic acid (VI). Finally, the Boc protecting group of (VI) was cleaved by means of trifluoroacetic acid.

1 Fisher, M.J.; Harms, C.S.; Giese, U.; et al.; Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere. Bioorg Med Chem Lett 2000, 10, 4, 385.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 34936 ethyl 2-(6-amino-1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)acetate C14H17NO3 详情 详情
(II) 28090 4-cyano-2-fluorobenzoic acid C8H4FNO2 详情 详情
(III) 34937 ethyl 2-[6-[(4-cyano-2-fluorobenzoyl)amino]-1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl]acetate C22H19FN2O4 详情 详情
(IV) 34938 ethyl 2-[6-([2-fluoro-4-[imino(methylsulfanyl)methyl]benzoyl]amino)-1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl]acetate C23H23FN2O4S 详情 详情
(V) 34939 ethyl 2-[6-([4-[[(tert-butoxycarbonyl)amino](imino)methyl]-2-fluorobenzoyl]amino)-1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl]acetate C27H30FN3O6 详情 详情
(VI) 34940 2-[6-([4-[[(tert-butoxycarbonyl)amino](imino)methyl]-2-fluorobenzoyl]amino)-1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl]acetic acid C25H26FN3O6 详情 详情
Extended Information