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【结 构 式】 
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【药物名称】Aspalatone, AAME, BK-111 【化学名称】Acetylsalicylic acid maltol ester 【CA登记号】147249-33-0 【 分 子 式 】C15H12O6 【 分 子 量 】288.25929 |
【开发单位】Bukwang (Originator) 【药理作用】Antiplatelet Therapy, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS |
合成路线1
Acetylsalicylic (I) acid was refluxed in SOCl2 to give acetylsalicylyl chloride (II), which is condensed with maltol (III) by means of triethylamine in chloroform to afford aspalatone.
| 【1】 Underwood, M.J.; More, R.S.; The aspirin papers. Brit Med J 1994, 308, 71-2. |
| 【2】 Han, B.H.; Suh, D.-Y.; Yang, H.O.; Park, Y.-H.; Kang, Y.H.; Kim, Y.C.; Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity. Arzneim-Forsch Drug Res 1994, 44, 10, 1122-6. |
| 【3】 Han, B.H.; Aspalatone. Drugs Fut 1995, 20, 11, 1109. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16899 | 2-(Acetoxy)benzoic acid; Aspirin; Acetylsalicylic acid | 50-78-2 | C9H8O4 | 详情 | 详情 |
| (II) | 16900 | 2-(chlorocarbonyl)phenyl acetate; Acetylsalicyloyl chloride | 5538-51-2 | C9H7ClO3 | 详情 | 详情 |
| (III) | 13671 | Hydroxymethylpyrone; 3-Hydroxy-2-methyl-4H-pyran-4-one；Maltol;3-Hydroxy-2-methyl-4-pyrone | 118-71-8 | C6H6O3 | 详情 | 详情 |
Extended Information